HCID 19754877, compound → HCID 19754890, compound

Participants

Reaction Steps

The compound prepared in Example 14 (800 mg, 1.81 mmol) in ethyl alcohol (20 mL) containing concentrated sulfuric acid (4 drops) was hydrogenated at 60 psi and room temperature using 5% Pd/C as catalyst. The catalyst was filtered and the filtrate concentrated in vacuo to give the crude product as an oil. The crude product was dissolved in ethyl acetate and washed twice with aqueous NaHCO3 solution and then with saturated aqueous NaCl solution. After drying (Na2SO4), the organic layer was filtered and concentrated in vacuo to give the title compound.

Provenance & Evidence