Benzoyl isothiocyanate → 5-(3-Benzoyl-thioureido)-1-methyl-1H-imidazole-4-carboxylic acid amide

Participants

Reaction Steps

5-Amino-1-methyl-1H-imidazole-4-carboxamide (6.5 g, 45 mM) and benzoylisothiocyanate (7.7 g, 47 mM) were refluxed in acetone (90 ml) for 4 hours under N2. After cooling in an ice bath the formed product was filtered off, washed with acetone and dried. Hereby was isolated 13.0 g (95%) of the title compound as a white powder, mp 194°-196° C.

Provenance & Evidence