反应详情

Combine 3-methoxybenzenamine (81.2 g, 0.66 mol) with N-(2-chloroethyl)-benzenemethanamine hydrochloride (45.3 g, 0.22 mol) and heat to 190° C. for 13 h. Add methylene chloride to precipitate a solid. Filter the solid and wash with methylene chloride. Triturate the solid with 100 mL of ethanol, filter the solid and wash with ethanol to give the title compound.

1. customAdd methylene chloride to precipitate a solid
2. filtrationFilter the solid
3. washwash with methylene chloride
4. customTriturate the solid with 100 mL of ethanol
5. filtrationfilter the solid
6. washwash with ethanol