4-[(Methylsulfonyl)amino]benzoyl chloride → 4-[(Methylsulfonyl)amino]-N-[[4-(3-methoxyphenyl)-1-(phenylmethyl)piperazin-2-yl]methyl]benzamide dihydrochloride

HRID 1588974Notes

Reaction equation

HRID 1588974 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:11]([CH2:22][NH2:23])[CH2:10]2)[CH:6]=[CH:7][CH:8]=1.[CH3:24][S:25]([NH:28][C:29]1[CH:37]=[CH:36][C:32]([C:33]([Cl:35])=[O:34])=[CH:31][CH:30]=1)(=[O:27])=[O:26]>>[ClH:35].[ClH:35].[CH3:24][S:25]([NH:28][C:29]1[CH:37]=[CH:36][C:32]([C:33]([NH:23][CH2:22][CH:11]2[CH2:10][N:9]([C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=3)[CH2:14][CH2:13][N:12]2[CH2:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[O:34])=[CH:31][CH:30]=1)(=[O:27])=[O:26]

Participants

3

Reactant 2

HCID 117911194-[(Methylsulfonyl)amino]benzoyl chlorideHCID 149987714-(3-Methoxyphenyl)-1-(phenylmethyl)-2-piperazinemethanamine

Product 1

HCID 197550214-[(Methylsulfonyl)amino]-N-[[4-(3-methoxyphenyl)-1-(phenylmethyl)piperazin-2-yl]methyl]benzamide dihydrochloride

Procedure

In a manner similar to Preparation 3, react 4-(3-methoxyphenyl)-1-(phenylmethyl)-2-piperazinemethanamine (3.1 g, 10 mmol) with 4-[(methylsulfonyl)amino]benzoyl chloride (3.3 g, 15 mmol) to obtain the title compound.

Workup

  1. customIn a manner similar to Preparation 3

Sources & evidence

ORD record
ord-c0b44ce03991424dad10b6aef40193d9
Source dataset
uspto-grants-1993_06
Patent number
US05223623

Reaction notes

Loading…