(Dimethyl sulfide)trihydroboron → 4-(3-Aminophenyl)-2-piperazinemethanol

HRID 1588995Notes

Reaction equation

HRID 1588995 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][NH:11][CH:10]([C:14](O)=[O:15])[CH2:9]2)[CH:5]=[CH:6][CH:7]=1.CSC.B>>[NH2:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][NH:11][CH:10]([CH2:14][OH:15])[CH2:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 12423031(Dimethyl sulfide)trihydroboronHCID 149988194-(3-Aminophenyl)-2-piperazinecarboxylic acid

Product 1

HCID 149988204-(3-Aminophenyl)-2-piperazinemethanol

Procedure

In a manner similar to Preparation 18, react 4-(3-aminophenyl)-2-piperazinecarboxylic acid with borane dimethylsulfide to obtain the title compound.

Workup

  1. customIn a manner similar to Preparation 18

Sources & evidence

ORD record
ord-cba1f5ad69c94966a525a503aa036350
Source dataset
uspto-grants-1993_06
Patent number
US05223623

Reaction notes

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