N-(3-Bromo-5-methoxyphenyl)-2-[[(3,4-dimethoxyphenyl)methyl]amino]acetamide → N-(3-bromo-5-methoxyphenyl)-N'-[(3,4-dimethoxyphenyl)methyl]-1,2-ethanediamine

HRID 1589008Notes

Reaction equation

HRID 1589008 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH:10][C:11](=O)[CH2:12][NH:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([O:23][CH3:24])[CH:16]=2)[CH:5]=[C:6]([O:8][CH3:9])[CH:7]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[Br:1][C:2]1[CH:3]=[C:4]([NH:10][CH2:11][CH2:12][NH:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([O:23][CH3:24])[CH:16]=2)[CH:5]=[C:6]([O:8][CH3:9])[CH:7]=1

Participants

3

Reactant 2

HCID 14998798N-(3-Bromo-5-methoxyphenyl)-2-[[(3,4-dimethoxyphenyl)methyl]amino]acetamideHCID 21226445Aluminium lithium hydride

Product 1

HCID 14998765N-(3-bromo-5-methoxyphenyl)-N'-[(3,4-dimethoxyphenyl)methyl]-1,2-ethanediamine

Procedure

In a manner similar to Preparation 2, react N-(3-bromo-5-methoxyphenyl)-2-[[(3,4-dimethoxyphenyl)methyl]amino]acetamide with lithium aluminum hydride to obtain the title compound.

Workup

  1. customIn a manner similar to Preparation 2

Sources & evidence

ORD record
ord-df43e5c5d8ce4ed095b725b2a10e0de1
Source dataset
uspto-grants-1993_06
Patent number
US05223623

Reaction notes

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