HCID 14998766, compound → HCID 14998775, compound

HRID 1589010Notes

Reaction equation

HRID 1589010 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][C:17]3[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[C:19]([O:25][CH3:26])[CH:18]=3)[CH:12]([C:27]([NH2:29])=O)[CH2:11]2)[CH:5]=[C:6]([O:8][CH3:9])[CH:7]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[Br:1][C:2]1[CH:3]=[C:4]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][C:17]3[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[C:19]([O:25][CH3:26])[CH:18]=3)[CH:12]([CH2:27][NH2:29])[CH2:11]2)[CH:5]=[C:6]([O:8][CH3:9])[CH:7]=1

Participants

3

Reactant 2

HCID 14998766HCID 14998766, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 14998775HCID 14998775, compound

Procedure

In a manner similar to Preparation 2, react 4-(3-bromo-5-methoxyphenyl)-1-[(3,4-dimethoxyphenyl)methyl]-2-piperazinecarboxamide with lithium aluminum hydride to obtain the title compound.

Workup

  1. customIn a manner similar to Preparation 2

Sources & evidence

ORD record
ord-fa5a9632aedb4c71a61c76009659ec86
Source dataset
uspto-grants-1993_06
Patent number
US05223623

Reaction notes

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