Tin atom → N-(4-Aminophenyl)-4-(4-ethoxyphenyl)-N-(2-methoxyethyl)-1-(phenylmethyl)-2-piperazinecarboxamide

HRID 1589021Notes

Reaction equation

[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH:12]([C:23]([N:25]([CH2:35][CH2:36][O:37][CH3:38])[C:26]3[CH:31]=[CH:30][C:29]([N+:32]([O-])=O)=[CH:28][CH:27]=3)=[O:24])[CH2:11]2)=[CH:6][CH:5]=1)[CH3:2].[Sn]>>[NH2:32][C:29]1[CH:28]=[CH:27][C:26]([N:25]([CH2:35][CH2:36][O:37][CH3:38])[C:23]([CH:12]2[CH2:11][N:10]([C:7]3[CH:8]=[CH:9][C:4]([O:3][CH2:1][CH3:2])=[CH:5][CH:6]=3)[CH2:15][CH2:14][N:13]2[CH2:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[O:24])=[CH:31][CH:30]=1

Participants

Reactant 2

HCID 5352426Tin atom

HCID 149988384-(4-Ethoxyphenyl)-N-(2-methoxyethyl)-N-(4-nitrophenyl)-1-(phenylmethyl)-2-piperazinecarboxamide

Product 1

HCID 14998839N-(4-Aminophenyl)-4-(4-ethoxyphenyl)-N-(2-methoxyethyl)-1-(phenylmethyl)-2-piperazinecarboxamide

Procedure

In a manner similar to Preparation 20, react 4-(4-ethoxyphenyl)-N-(2-methoxyethyl)-N-(4-nitrophenyl)-1-(phenylmethyl)-2-piperazinecarboxamide with tin II chloride to obtain the title compound.

Workup

customIn a manner similar to Preparation 20

Sources & evidence

ORD record: ord-f55a1a955a064ce4b9cf00cee1c73520
Source dataset: uspto-grants-1993_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05223623

Reaction notes

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