18-Crown-6 → HCID 13579269, compound

Participants

Reaction Steps

In this example, a mixture containing 3 g of 2-bromo-3-oxo-4-(3-trifluoromethylphenyl)-5-dimethylamino-2,3-dihydrofuran, 0.26 of 18-Crown-6 ether and 1.11 g of potassium fluoride in 20 ml of acetonitrile was stirred at room temperature for about 30 minutes and then refluxed overnight (about 16 hours). The mixture was then cooled, filtered, and then concentrated by evaporation. The residue was chromatographed eluting with 3 vol. % tetrahydrofuran:97% chloroform affording the title compound.

Provenance & Evidence