Dimethyl Sulfate → HCID 13579373, compound

Participants

Reaction Steps

In this example, 0.60 g of solid sodium hydroxide in 4.0 ml of water was added to a mixture of 4.1 g of 2-phenyl-3-oxo-4-(3-methoxycarbonylphenyl)-5-amino-2,3-dihydrofuran in 70 ml of methylene chloride at room temperature followed by the addition of 1.73 g of dimethyl sulfate and 0.30 g of benzyltriethyl ammonium chloride. The two-phase mixture was then stirred at room temperature for about 18 hours and then washed one time with water, dried over magnesium sulfate and then concentrated by evaporation under vacuum to yield an oil. The oil was triturated with 1:1 diethyl ether:methanol to afford 2.3 g of the title compound as a white powder.

Provenance & Evidence