O-Methylhydroxylamine → 1-(4,6-dimethoxy-1,3,5-triazin-2-yl)-3-methoxy-2-(2-phenylphenyl)sulfonylguanidine

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Reaction Steps

4.45 g of 1-(2-biphenylylsulfonyl) 3-(4,6-dimethoxy-1,3,5-triazin-2-yl) 2-methylisothiourea were dissolved in 50 ml of dioxane, and 2.35 g of O-methylhydroxylamine were added to the solution. The mixture was heated under reflux for 5 hours. After cooling, the solvent was distilled off under reduced pressure, and the residue was recrystallized from ethanol to give 3.1 g of N-(2-biphenylylsulfonyl) N'-(4,6-dimethoxy-1,3,5-triazin-2-yl) N"-(methoxy)guanidine represented by the following formula: ##STR30##

Provenance & Evidence