Glycine → Glyphosate

HRID 1589108Notes

Reaction equation

[CH:1]([P:3](=[O:6])([OH:5])[OH:4])=O.[NH2:7][CH2:8][C:9]([OH:11])=[O:10]>>[CH2:8]([NH:7][CH2:1][P:3]([OH:4])([OH:5])=[O:6])[C:9]([OH:11])=[O:10]

Participants

Reactant 2

HCID 750Glycine

HCID 10154022Formylphosphonic Acid

Product 1

HCID 3496GlyphosateYield 90%

Procedure

Reaction of formylphosphonic acid and glycine was carried out under the conditions described in Example 6 except that the pH was adjusted to 10.0 before commencement of the reduction reaction. Analysis indicated a 90.0% yield of glyphosate salts.

Workup

customwas adjusted to 10.0 before commencement of the reduction reaction

Sources & evidence

ORD record: ord-cef81218ec8b444099534f6233389600
Source dataset: uspto-grants-1986_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04568432

Reaction notes

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