4-Chlorobenzoyl chloride → HCID 13588904, compound

HRID 1589169Notes

Reaction equation

HRID 1589169 reaction equation
Cl.Cl.[N:3]1([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][NH2:13])[CH:7]=[N:6][CH:5]=[N:4]1.[OH-].[Na+].[Cl:16][C:17]1[CH:25]=[CH:24][C:20]([C:21](Cl)=[O:22])=[CH:19][CH:18]=1>C(Cl)Cl>[Cl:16][C:17]1[CH:25]=[CH:24][C:20]([C:21]([NH:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][N:3]2[CH:7]=[N:6][CH:5]=[N:4]2)=[O:22])=[CH:19][CH:18]=1

Participants

5

Reactant 3

HCID 85014-Chlorobenzoyl chlorideHCID 14798Sodium Hydroxide2×HCID 20248322HCID 20248322, compound

Product 1

HCID 13588904HCID 13588904, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A mixture of about 2.30 g of 1H-1,2,4-triazole-1-pentanamine dihydrochloride, about 75 ml of methylene chloride, about 30 ml of approximately 1N sodium hydroxide and about 1.2 ml of 4-chloro benzoyl chloride was stirred for about 18 hours, then about 5 ml of approximately 1N sodium hydroxide and about 50 ml of methylene chloride were added and the layers were separated. The organic layer was washed with water dried and concentrated, giving the desired product, mp 68°-70° C.

Workup

  1. customthe layers were separated
  2. washThe organic layer was washed with water
  3. customdried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-4a615a0973aa43df8c97f8348b67294d
Source dataset
uspto-grants-1986_02
Patent number
US04568685

Reaction notes

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