Ethanol → HCID 86740649, compound

HRID 1589172Notes

Reaction equation

HRID 1589172 reaction equation
[NH:1]1[N:5]2[CH2:6][C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=3[CH:4]2[CH2:3][CH2:2]1.[ClH:13].[C:14](=[NH:19])([O:16]CC)[CH3:15].C([OH:22])C>>[ClH:13].[C:15]1(=[O:22])[N:19]([N:1]2[N:5]3[CH2:6][C:7]4[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=4[CH:4]3[CH2:3][CH2:2]2)[C:14]1=[O:16]

Participants

4

Reactant 3

HCID 702EthanolHCID 2724290Ethanimidic acid, ethyl ester, hydrochloride (1:1)HCID 133657202,3,3a,8-Tetrahydro-1H-pyrazolo[5,1-a]isoindole

Product 1

HCID 86740649HCID 86740649, compound

Procedure

3.1 g (0.019 mol) of 2,3,3a,8-tetrahydro-1H-pyrazolo[5,1-a]isoindole and 3.3 g (0.03 mol) of ethyl acetimidate hydrochloride in 100 ml of absolute ethanol are stirred at room temperature for 15 hours. After removing the ethanol, the residue of 1-acetimido-2,3,3a,8-tetrahydro-1H-pyrazolo[5,1-a]isoindole hydrochloride is crystallised using ethyl acetate/isopropanol. Melting point 255°-257° C. (decomposition).

Workup

  1. customAfter removing the ethanol
  2. customthe residue of 1-acetimido-2,3,3a,8-tetrahydro-1H-pyrazolo[5,1-a]isoindole hydrochloride is crystallised

Sources & evidence

ORD record
ord-46068af407114dffb3270d8195900dcb
Source dataset
uspto-grants-1986_02
Patent number
US04568688

Reaction notes

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