反应详情

A solution of 1.05 g. of 3,4-dichlorobenzoyl chloride in 25 ml. of methylene chloride was added to a stirred solution of 1.06 g. of 1H-imidazole-1-butanamine dihydrochloride in 15 ml. of 1N sodium hydroxide. The mixture was stirred for 18 hours, methylene chloride was added and the layers were separated. The organic layer was washed with water, dried over magnesium sulfate and concentrated. The residue was washed onto a filter with diethyl ether, giving the desired product, m.p. 86°-88° C.

1. customthe layers were separated
2. washThe organic layer was washed with water
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated
5. washThe residue was washed onto
6. filtrationa filter with diethyl ether