Sodium Hydroxide → HCID 13588943, compound

HRID 1589178Notes

Reaction equation

HRID 1589178 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[Cl:11])[C:5](Cl)=[O:6].Cl.Cl.[N:14]1([CH2:19][CH2:20][CH2:21][CH2:22][NH2:23])[CH:18]=[CH:17][N:16]=[CH:15]1.[OH-].[Na+]>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[Cl:11])[C:5]([NH:23][CH2:22][CH2:21][CH2:20][CH2:19][N:14]1[CH:18]=[CH:17][N:16]=[CH:15]1)=[O:6]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 76403Benzoyl chloride, 3,4-dichloro-HCID 128033264-(Imidazole-1-yl)butylamine dihydrochloride

Product 1

HCID 13588943HCID 13588943, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 1.05 g. of 3,4-dichlorobenzoyl chloride in 25 ml. of methylene chloride was added to a stirred solution of 1.06 g. of 1H-imidazole-1-butanamine dihydrochloride in 15 ml. of 1N sodium hydroxide. The mixture was stirred for 18 hours, methylene chloride was added and the layers were separated. The organic layer was washed with water, dried over magnesium sulfate and concentrated. The residue was washed onto a filter with diethyl ether, giving the desired product, m.p. 86°-88° C.

Workup

  1. customthe layers were separated
  2. washThe organic layer was washed with water
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated
  5. washThe residue was washed onto
  6. filtrationa filter with diethyl ether

Sources & evidence

ORD record
ord-d79c36b544e74bfd929a6106570b8315
Source dataset
uspto-grants-1986_02
Patent number
US04568687

Reaction notes

Loading…