反应详情

A mixture of 2.0 g. of 4-phenyl-1H-imidazole-1-propanamine, 50 ml. of methylenechloride and 10 ml. of 1N sodium hydroxide was stirred and 2.2 g. of 4-bromobenzoyl chloride was added. The mixture was stirred for eighteen hours, methylene chloride was added and the layers were separated. The organic layer was washed with water, dried over magnesium sulfate and concentrated. The residue was washed onto a filter with ether, giving the desired product, m.p. 132°-135° C.

1. additionA mixture of 2.0 g
2. customthe layers were separated
3. washThe organic layer was washed with water
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated
6. washThe residue was washed onto
7. filtrationa filter with ether