Imidazole → 3-(1H-Imidazol-1-yl)butan-1-amine

HRID 1589189Notes

Reaction equation

[C:1](#[N:5])/[CH:2]=[CH:3]/[CH3:4].[NH:6]1[CH:10]=[CH:9][N:8]=[CH:7]1>>[N:6]1([CH:3]([CH3:4])[CH2:2][CH2:1][NH2:5])[CH:10]=[CH:9][N:8]=[CH:7]1

Participants

Reactant 2

HCID 795Imidazole

HCID 637921Crotononitrile

Product 1

HCID 139528623-(1H-Imidazol-1-yl)butan-1-amine

Procedure

When crotononitrile is reacted with imidazole by the procedure of Example 113, 3-(1H-imidazol-1-yl)butanamine is obtained as an oil. By reaction of this diamine with the appropriate benzoyl chloride by the procedure of Example 27, the products set forth in Table XVIII below are obtained.

Sources & evidence

ORD record: ord-76c9754dc7594f8883ae7eb44e952182
Source dataset: uspto-grants-1986_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04568687

Reaction notes

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