反应详情

A suspension of 7.7 g of 2-amino-3-[hydroxy(phenyl)methyl]benzene ethanol in 250 ml of benzene was treated with 14 g of activated Manganese dioxide and refluxed for 5 hours using a Dean-Stark trap. The hot mixture obtained was then filtered through Celite and the filtrate stripped to yield a dark oil. The oily material was placed on a florisil column and eluted with a benzene-acetone mixture. The isolated product was recrystallized from ethanol-pet. ether (30:60) to give the titled compound as yellow needles, m.p. 107°-108° C.

1. temperaturerefluxed for 5 hours
2. customThe hot mixture obtained
3. filtrationwas then filtered through Celite
4. customto yield a dark oil
5. washeluted with a benzene-acetone mixture
6. customThe isolated product was recrystallized from ethanol-pet. ether (30:60)