HCID 13577662, compound → HCID 13577668, compound

Participants

Reaction Steps

A mixture of 6.0 g (0.022 mole) of 2-amino-3-[(4-chlorophenyl)hydroxymethyl]benzene ethanol, 8.7 g (0.10 mole) of activated manganese dioxide and 250 ml of benzene was heated at reflux utilizing a Dean-Stark trap for 5 hours. The hot mixture obtained was filtered through Celite and the filtrate was concentrated to give a solid residue. This residue was recrystallized successively from carbon tetrachloride, cyclohexane and benzene, and 2-propanol to yield 2.9 g (48%) of the titled compound as a yellow solid,

Provenance & Evidence