Acetic Acid → HCID 13609084, compound

Participants

Reaction Steps

A solution of 2,6-diisopropylaniline (35.45 g, 0.20 mol), 37% aqueous formaldehyde (16.2 mL, 0.20 mol), morpholine (17.42 g, 0.20 mol), acetic acid (6.00 g, 0.10 mol), and ethanol (25 mL) were reacted under conditions similar to Example 1. After concentration on the rotary evaporator, the residue was dissolved in diethyl ether and washed with aqueous sodium bicarbonate and water. After drying the ether solution, a solution of hydrogen chloride (0.20 mol) in ethanol was added. Filtration and drying gave the hydrochloride salt of the title compound (47.58 g, 76.0%). The salt (20.0 g, 0.6 mol) was dissolved in acetone and treated with solid potassium bicarbonate. Upon filtration and evaporation of solvent, the title compound was obtained (16.27 g, 92.2%).

Provenance & Evidence