Methanol → Epibromohydrin

In a 500-ml flask, 65 g of 2,3-dibromopropyl acetate (0.25 mole), 10 ml of water, 100 ml of methanol and 44 g of 50 percent sodium hydroxide (0.55 mole) are mixed giving an exothermic reaction. The mixture is then stirred at 60° C.-65° C. for 5 hours and allowed to cool. To this mixture is added 200 ml of water but no phasing occurs. The water phase is extracted twice with 150-ml portions of methylene chloride and these layers dried over sodium sulfate, filtered and distilled to give a 100 percent conversion of the 2,3-dibromopropyl acetate with a 38 percent yield of epibromohydrin.

1. customgiving
2. customan exothermic reaction
3. temperatureto cool
4. extractionThe water phase is extracted twice with 150-ml portions of methylene chloride
5. dry with materialthese layers dried over sodium sulfate
6. filtrationfiltered
7. distillationdistilled

ORD record

ord-061f60a218bc4687a091bdcfd7dafff6

Source dataset

uspto-grants-1986_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04568759