HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-Methyl-1H-indene-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 2-Benzyl-3-oxobutanoic acid | HCID 13093868 | — |
| Reactant | HCID 20195157 | HCID 20195157 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Product | 1-Methyl-1H-indene-2-carboxylic acid | HCID 12398744 | — |
| Product | HCID 20195156 | HCID 20195156 | — |
Reaction Steps
Similarly, 5-amino-2-methylindene was prepared from the reductive cyclization of 3-(m-nitrophenyl)-2-methylpropionaldehyde with zinc and hydrochloric acid at elevated temperatures. Miller W. v. and Kinkelin G. Ber. 1886, 19, 1249 and 1520; Miller, W. v. and Rohde, G. ibid 1889, 22, 1830-1843. The difunctional 3-carboxy-4-phenyl-2-butanone reacted with excess sulfuric acid to give an unspecified yield of 1-methyl-2-carboxyindene. Roser, W. Ber. 1887, 20, 1574-1576.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04568782 |
| Source dataset | uspto-grants-1986_02 |
| ORD ID | ord-cd8cc3ba7b0e481795684d28bb4615de |
| Source note | uspto-grants-1986_02 |