Bromine → HCID 70456026, compound

HRID 1589298Notes

Reaction equation

HRID 1589298 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([S:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[N:20]=[C:14]2[C:15](=[O:19])[NH:16][CH2:17][CH:18]=[C:13]2[N:12]=1.C([O-])(=[O:23])C.[Na+].BrBr>C(O)(=O)C>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([S:9]([CH3:10])=[O:23])[CH:6]=[CH:5][C:4]=1[C:11]1[N:20]=[C:14]2[C:15](=[O:19])[NH:16][CH2:17][CH:18]=[C:13]2[N:12]=1

Participants

5

Reactant 3

HCID 24408BromineHCID 517045Sodium AcetateHCID 70455630HCID 70455630, compound

Product 1

HCID 70456026HCID 70456026, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

0.3 g of 2-(2-methoxy-4-methylmercapto-phenyl)-5H-imidazo[4,5-c]pyridin-4-one were suspended in 10 ml of 50% acetic acid, and 0.2 g of anhydrous sodium acetate were added thereto. 0.15 g of bromine, dissolved in 2 ml of glacial acetic acid, was added dropwise to the mixture, while stirring. After the reaction had ended the mixture was poured over ice, and the precipitate thus obtained was recrystallized from ethanol. Melting point: 267°-272° C. (decomposition).

Workup

  1. additionwas added dropwise to the mixture
  2. additionwas poured over ice
  3. customthe precipitate thus obtained
  4. customwas recrystallized from ethanol

Sources & evidence

ORD record
ord-fc11ee5874bc4708a1c6d4bce9ae20f3
Source dataset
uspto-grants-1986_02
Patent number
US04568680

Reaction notes

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