HCID 14505566, compound → HCID 18601575, compound

HRID 1589314Notes

Reaction equation

HRID 1589314 reaction equation
[ClH:1].[CH3:2][NH:3][C:4](=[O:22])[C@H:5]([CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14]CC2C=CC=CC=2)=[CH:10][CH:9]=1)[NH2:6].[H][H]>CO.[Pd]>[ClH:1].[CH3:2][NH:3][C:4](=[O:22])[C@H:5]([CH2:7][C:8]1[CH:9]=[CH:10][C:11]([OH:14])=[CH:12][CH:13]=1)[NH2:6]

Participants

5

Reactant 2

HCID 14505566HCID 14505566, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18601575HCID 18601575, compoundYield 104.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of O-benzyl-L-tyrosine N-methylamide HCl (1.13 g) in methanol (50 ml) was added 10% Pd/C and the mixture was stirred in an atmosphere of hydrogen at room temperature and atmospheric pressure for 4 h. The catalyst was then filtered and the solvent was removed in vacuo to yield L-tyrosine N-methylamide HCl as a foam (0.85 g).

Workup

  1. filtrationThe catalyst was then filtered
  2. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-732df62a706846c88394d2211e6e8f0a
Source dataset
uspto-grants-1986_02
Patent number
US04568666

Reaction notes

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