H-Leu-Gly-OEt.HCl → HS-Leu-Ala-Gly-OC2H5

HRID 1589350Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1589350
[SH:1][NH:2][C@H:3]([C:8]([NH:10][C@H:11]([C:16]([NH:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])=[O:17])[CH2:12]C(C)C)=[O:9])[CH2:4][CH:5]([CH3:7])[CH3:6].Cl.C(OC(=O)CNC(=O)[C@H](C)N)C.Cl.C(OC(=O)CNC(=O)[C@H](CC(C)C)N)C>>[SH:1][NH:2][C@H:3]([C:8]([NH:10][C@H:11]([C:16]([NH:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])=[O:17])[CH3:12])=[O:9])[CH2:4][CH:5]([CH3:7])[CH3:6]

Komponenten

4

Edukt 3

HCID 13334684H-Leu-Gly-OEt.HClHCID 14189604L-alanylglycine ethyl ester hydrochlorideHCID 131714519HS-Leu-Leu-Gly-OC2H5

Produkt 1

HCID 131714520HS-Leu-Ala-Gly-OC2H5

Versuchsvorschrift

This mercaptopeptidyl ester was prepared substantially similarly as HS-Leu-Leu-Gly-OC2H5, above, except that an equivalent amount of L-alanylglycine ethyl ester hydrochloride was used in the coupling reaction instead of L-leucylglycine ethyl ester hydrochloride.

Quellen und Nachweise

ORD-Eintrag
ord-c91968d4425544dea19d9ae911277ba7
Quelldatensatz
uspto-grants-1986_02
Patentnummer
US04569907

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