Acetic Acid → HCID 4266103, compound

HRID 1589412Notes

Reaction equation

HRID 1589412 reaction equation
[C:1]1(=O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.C(O)(=O)C.[C:15]([O:19][CH3:20])(=[O:18])[NH:16][NH2:17]>CO>[CH3:20][O:19][C:15](=[O:18])[NH:16][N:17]=[C:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 67351-IndanoneHCID 80519Methyl carbazate

Product 1

HCID 4266103HCID 4266103, compoundYield 91.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 39.65 g (0.3 moles) of 1-indanone in 300 ml of methanol 3 ml of acetic acid and 27 g (0.3 moles) of methyl carbazate are added. The reaction mixture is boiled in a flask equipped with a reflux condenser for one hour, then clarified with bone coal, filtered and the filtrate is cooled with icy water. 43.7 g of the desired compound are obtained in the form of white crystals. M.p.: 155°-156° C. The mother liquor is evaporated in vacuo to about one-fourth of its original volume. In this way a another 12.3 g of the desired compound are obtained. Yield: 91.5%.

Workup

  1. customThe reaction mixture is boiled in a flask
  2. customequipped with a reflux condenser for one hour
  3. filtrationfiltered
  4. temperaturethe filtrate is cooled with icy water

Sources & evidence

ORD record
ord-35e008ca0c1642f69626cd525caa2cec
Source dataset
uspto-grants-1986_02
Patent number
US04570002

Reaction notes

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