Sodium Chloride → HCID 14249478, compound

Participants

Reaction Conditions

Reaction Steps

4.23 g of sodium azide is dissolved in a mixture of 50 ml of water and 100 ml of dioxane. The solution is heated to 60° C., 8.65 g of 2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethylene oxide in 10 ml of dioxane is added dropwise thereto, and the mixture is heated for 2 hours to 80° C. After cooling, the aqueous phase is saturated with sodium chloride. The organic phase is separated, dried over sodium sulfate, and concentrated to dryness under vacuum. The residue is distilled with a water-jet aspirator. 2-Azido-(2,2-dimethyl-1,3-dioxolan-4-yl)ethanol passes over at 130°-132° C./13 mm as a colorless oil. Yield: 9.1 g (81% of theory).

Provenance & Evidence