HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Indapamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Phosphoric Acid | HCID 1004 | — |
| Reactant | 1-Allyl-1-phenyl-2-(3-sulfamoyl-4-chlorobenzoyl)-hydrazine | HCID 15571502 | — |
| Product | Indapamide | HCID 3702 | — |
Reaction Steps
A mixture of 1-allyl-1-phenyl-2-(3-sulfamoyl-4-chlorobenzoyl)-hydrazine (36.6g, 0.1 mole) and orthophosphoric acid, 85% (100 ml) was stirred at 60° for a period of 4 hours. Dilution with water gave crude 1-(4-chloro-3-sulfamoylbenzamido)-2-methylindoline which was purified by recrystallization from isopropanol-n-hexane (60:40).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04570001 |
| Source dataset | uspto-grants-1986_02 |
| ORD ID | ord-ec1c73e105054305b6fcb2bb7850f3bb |
| Source note | uspto-grants-1986_02 |