反应详情

温度

130 °C

A mixture of 5 g of 3-chloro-6-(3-pyridinyl)pyridazine and 30 ml of 2-amino-1-propanol is heated at 130° C. for 24 hours and the volatiles removed by bulb to bulb distillation under high vacuum to obtain the product 2-[[6-(3-pyridinyl)-3-pyridazinyl]amino]-1-propanol. As for Example 5, the preceding product is reacted with thionyl chloride and the obtained product is ring closed with potassium carbonate in ethanol to give 2,3-dihydro-2-methyl-6-(3-pyridinyl)imidazo[1,2-b]pyridazine which is dehydrogenated with lead tetraacetate to give 2-methyl-6-(3-pyridinyl)imidazo[1,2-b]pyridazine.

1. customthe volatiles removed by bulb to bulb distillation under high vacuum