HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 20246580, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Amino-1-butanol | HCID 22129 | — |
| Reactant | 3-Chloro-6-(pyridin-3-yl)pyridazine | HCID 16732435 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 20246580 | HCID 20246580 | — |
Reaction Conditions
| Temperature | 130 °C |
|---|
Reaction Steps
A mixture of 5 g of 3-chloro-6-(3-pyridinyl)pyridazine and 30 ml of 2-amino-1-butanol is heated at 130° C. for 18 hours. Then the volatiles are removed by bulb to bulb distillation under high vacuum. As for Example 1, the product is reacted with thionyl chloride and the obtained product is ring closed with potassium carbonate in ethanol to give 2,3-dihydro-3-ethyl-6-(3-pyridinyl)imidazo[1,2-b]pyridazine which is dehydrogenated with lead tetraacetate in dichloromethane to give the desired product 3-ethyl-6-(3-pyridinyl)imidazo[1,2-b]pyridazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04569934 |
| Source dataset | uspto-grants-1986_02 |
| ORD ID | ord-f31dae7c8b7c42a38a6fcc805f63503b |
| Source note | uspto-grants-1986_02 |