Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 3-Amino-6-(3-trifluoromethylphenyl)pyridazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | 3-Hydrazinyl-6-[3-(trifluoromethyl)phenyl]pyridazine | HCID 12726855 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Nickel | HCID 935 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3-Amino-6-(3-trifluoromethylphenyl)pyridazine | HCID 13565367 | — |
반응 단계
Alternatively, 5.0 g of 3-hydrazino-6-[3-(trifluoromethyl)phenyl]pyridazine, 100 ml of ethanol, 10 ml of water and Raney nickel catalyst was shaken with hydrogen under 40 pounds of pressure in a Parr apparatus for 18 hours. The mixture was cooled and filtered and the filtrate concentrated to a gummy soid which was crystallized from dichloromethane-hexane to give 3-amino-6-[3-(trifluoromethyl)phenyl]pyridazine as off-white crystals, mp 138°-139° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04569934 |
| 출처 데이터셋 | uspto-grants-1986_02 |
| ORD ID | ord-43f6a12e4a144161ad3d5225df8e846f |
| 출처 메모 | uspto-grants-1986_02 |