反应详情

A 1.5 g sample of 3-amino-6-[3-(trifluoromethyl)phenyl]pyridazine, 1.23 g of bromoacetone and 50 ml of ethanol was refluxed for 18 hours. The volatiles were removed in vacuo and the residue dissolved in dichloromethane. The solution was treated with activated carbon, filtered, and concentrated. The residue was crystallized from dichloromethane-hexane to give 1.0 g of the desired product as cream colored crystals, mp 219°-221° C.

1. customThe volatiles were removed in vacuo
2. dissolutionthe residue dissolved in dichloromethane
3. additionThe solution was treated with activated carbon
4. filtrationfiltered
5. concentrationconcentrated
6. customThe residue was crystallized from dichloromethane-hexane