Pyridine → HCID 178492415, compound

Participants

Reaction Steps

To 40 ml of anhydrous pyridine, was added 2.1 g of 6-guanidinocaproic acid hydrochloride. To the mixture, while being cooled in ice, was added 2.5 g of DCC. The mixture was stirred for one hour, admixed with 2.6 g of 4-amidino-2-methoxyphenol methanesulfonate, and further stirred overnight at room temperature. After addition of ethyl ether to the reaction mixture, the supernatant was removed to obtain an oily substance as the residue. The oily substance was dissolved in DMF, then freed from insolubles by filtration, and mixed with ethyl ether to obtain 4.0 g of a colorless oily substance. This substance was dissolved in water by heating, then treated with activated carbon, and mixed with acetone to isolate 3.5 g of 4-amidino-2-methoxyphenyl 6-guanidinocaproate methanesulfonate hydrochloride in the form of colorless oil.

Provenance & Evidence