HCID 178419259, compound → HCID 178498199, compound

Participants

Reaction Steps

To 9.0 ml of a 30% hydrogen bromide-acetic acid mixture, was added 2.8 g of 4-amidino-2-methoxycarbonylphenyl trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylate methanesulfonate. The mixture was stirred for one hour at room temperature, meanwhile the crystals dissolved in a few minutes, forming a uniform yellow solution. The reaction mixture was mixed with ethyl ether, and the crystals were collected by filtration, washed with ethyl ether, and dried to obtain 3.1 g a dried product. The dried product was recrsytallized from ethanol to obtain 1.3 g of colorless granular crystals of 4-amidino-2-methoxycarbonylphenyl trans-4-aminomethylcyclohexane carboxylate dihydrobromide.

Provenance & Evidence