Phosphorus pentachloride → 4-(ACETYLOXY)-2-METHYL-BENZOYL CHLORIDE

HRID 1589481Notes

Reaction equation

HRID 1589481 reaction equation
[C:1]([O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9](O)=[O:10])=[C:7]([CH3:14])[CH:6]=1)(=[O:3])[CH3:2].P(Cl)(Cl)(Cl)(Cl)[Cl:16]>C(OCC)C>[C:1]([O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([Cl:16])=[O:10])=[C:7]([CH3:14])[CH:6]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 24819Phosphorus pentachlorideHCID 11183157HCID 11183157, compound

Product 1

HCID 112528444-(ACETYLOXY)-2-METHYL-BENZOYL CHLORIDE

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

In 60 ml of anhydrous ethyl ether, was suspended 6.2 g of 4-acetyloxy-2-methylbenzoic acid. To the suspension, was added 8.0 g of phosphorus pentachloride. The suspension was stirred for 3 hours at room temperature. The reaction mixture was freed from the solvent by distillation under reduced pressure, admixed again with ethyl ether, and freed from the solvent by distillation to obtain 4-acetyloxy-2-methylbenzoyl chloride.

Workup

  1. distillationThe reaction mixture was freed from the solvent by distillation under reduced pressure
  2. distillationfreed from the solvent by distillation

Sources & evidence

ORD record
ord-f074f3b03445442dadedc7a2ba2d5890
Source dataset
uspto-grants-1986_02
Patent number
US04570006

Reaction notes

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