Pyridine → HCID 13178456, compound

Participants

Reaction Steps

Into 30 ml of pyridine, was dissolved 1.7 g of 4-amidino-2-aminophenol dimethanesulfonate. To the solution, while being cooled in ice and stirred, was added 1.8 g of benzoyl chloride. The mixture was stirred for 30 minutes while cooling in ice and 2 hours at room temperature. The reaction mixture was admixed with about 100 ml of ethyl ether to allow a colorless oily substance to separate out. The solvent was removed by decantation and the residue was dissolved in a small volume of ethanol. Upon addition of a saturated aqueous sodium hydrogencarbonate solution, colorless crystals of 4-amidino-2-benzoylaminophenyl benzoate carbonate were precipitated. The crystals were collected by filtration, washed with water, then with acetone, and suspended in ethanol. On addition of methanesulfonic acid, the suspension turned into a clear solution. Ethyl ether was added to the solution to precipitate crystals. The crystals were collected by filtration and recrystallized from an ethanol-ethyl ether mixture to obtain 1.4 g of colorless crystals of 4-amidino-2-benzoylaminophenyl benzoate methanesulfonate.

Provenance & Evidence