反应详情

To a mixture of 3.4 g of 4-benzyloxybenzoic acid and 50 ml of dried pyridine, while being cooled in ice, was added 3.7 g of DCC. After having been stirred for 30 minutes, the mixture was admixed with 5.0 g of 4-amidino-2-benzoylphenol methanesulfonate and stirred overnight at room temperature. The reaction mixture was freed from the insolubles by filtration and mixed with ethyl ether. The precipitated insoluble substance was recrystallized from a methanol-ethyl ether mixture to obtain 5.2 g of colorless crystals of 4-amidino-2-benzoylphenyl 4-benzoyloxybenzoate methanesulfonate.

1. temperaturewhile being cooled in ice
2. stirringstirred overnight at room temperature
3. filtrationThe reaction mixture was freed from the insolubles by filtration
4. additionmixed with ethyl ether
5. customThe precipitated insoluble substance was recrystallized from a methanol-ethyl ether mixture