反应详情

To a mixture of 3.1 g of 4-acetyloxycinnamic acid and 50 ml of dried pyridine, while being cooled in ice, was added 3.7 g of DDC. To the mixture, after having been stirred for 30 minutes, was added 5.0 g of 4-amidino-2-benzoylphenol methanesulfonate. The mixture was stirred overnight at room temperature. The insolubles precipitated from the reaction mixture were collected by filtration and mixed with DMF. Ethyl ether was added to the supernatant to precipitate an insoluble substance which was recrystallized from ethanol, yielding 4.7 g of colorless crystals of 4-amidino-2-benzoylphenyl 4-acetyloxycinnamate methanesulfonate.

1. temperaturewhile being cooled in ice
2. additionwas added 3.7 g of DDC
3. stirringThe mixture was stirred overnight at room temperature
4. customThe insolubles precipitated from the reaction mixture
5. filtrationwere collected by filtration
6. additionmixed with DMF
7. additionEthyl ether was added to the supernatant
8. customto precipitate an insoluble substance which
9. customwas recrystallized from ethanol