Dicyclohexylcarbodiimide → 4-Amidino-2-benzoylphenyl 4-dimethylaminobenzoate methanesulfonate

HRID 1589508Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1589508
[CH3:1][N:2]([CH3:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1.C1CCC(N=C=NC2CCCCC2)CC1.[CH3:28][S:29]([O:32][C:33]1[CH:38]=[CH:37][C:36]([C:39](=[NH:41])[NH2:40])=[CH:35][C:34]=1[C:42](=[O:49])[C:43]1[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=1)(=[O:31])=[O:30]>N1C=CC=CC=1>[CH3:28][S:29]([OH:32])(=[O:31])=[O:30].[CH3:1][N:2]([CH3:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7]([O:9][C:33]2[CH:38]=[CH:37][C:36]([C:39](=[NH:40])[NH2:41])=[CH:35][C:34]=2[C:42](=[O:49])[C:43]2[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=2)=[O:8])=[CH:5][CH:4]=1

Komponenten

5

Edukt 3

HCID 10868DicyclohexylcarbodiimideHCID 120924-(Dimethylamino)benzoic acidHCID 540991824-Amidino-2-benzoylphenol methanesulfonate

Produkt 1

HCID 202471194-Amidino-2-benzoylphenyl 4-dimethylaminobenzoate methanesulfonateAusbeute 24,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

In 50 ml of dried pyridine, was dissolved 1.65 g of 4-dimethylaminobenzoic acid followed by the addition of 3.1 g of DCC. After 30 minutes of stirring, 3.36 g of 4-amidino-2-benzoylphenol methanesulfonate was added to the mixture and the mixture was further stirred overnight. The reaction mixture was removed of the insolubles by filtration and recrystallized from ethanol to yield 1.2 g of 4-amidino-2-benzoylphenyl 4-dimethylaminobenzoate methanesulfonate.

Aufarbeitung

  1. waitthe mixture was further stirred overnight
  2. customThe reaction mixture was removed of the insolubles by filtration
  3. customrecrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-24bb7bd811594f66a9722e9aa55d4e7d
Quelldatensatz
uspto-grants-1986_02
Patentnummer
US04570006

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