反应详情

To a solution of 11.6 g of 4-guanidinobenzoic acid hydrochloride in 180 ml of dried pyridine, while being cooled in ice, was added 13.2 g of DCC. After 30 minutes of stirring, 18.0 g of 4-amidino-2-benzoylphenol methanesulfonate was added, and the mixture was further stirred overnight at room temperature. A white solid substance precipitated from the reaction mixture was collected by filtration, washed with acetone, and dissolved in water. The aqueous solution was freed from the water-insoluble DCU by filtration and added to a saturated aqueous sodium bicarbonate solution, while being cooled in ice and stirred. The precipitated pale yellow crystals were collected by filtration, washed with water, then with acetone, and dried to yield 4-amidino-2-benzoylphenyl 4-guanidinobenzoate carbonate.

1. waitthe mixture was further stirred overnight at room temperature
2. customA white solid substance precipitated from the reaction mixture
3. filtrationwas collected by filtration
4. washwashed with acetone
5. dissolutiondissolved in water
6. filtrationThe aqueous solution was freed from the water-insoluble DCU by filtration
7. additionadded to a saturated aqueous sodium bicarbonate solution
8. temperaturewhile being cooled in ice
9. stirringstirred
10. filtrationThe precipitated pale yellow crystals were collected by filtration
11. washwashed with water
12. dry with materialwith acetone, and dried