HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1589536Generated: November 1, 2026
N-(2,3-Epoxypropyl)phthalimide → 2-[2-Hydroxy-3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1H-isoindole-1,3-(2H)-dione
https://huagongshe.com/reaction/1589536
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-(2,3-Epoxypropyl)phthalimide | HCID 21601 | — |
| Reactant | 1-(3-Hydroxybenzyl)piperidine | HCID 826974 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 2-[2-Hydroxy-3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1H-isoindole-1,3-(2H)-dione | HCID 13469034 | 100.1% |
Reaction Steps
A mixture of 2-(oxiranylmethyl)-1H-isoindole-1,3-(2H)-dione (9.10 g) and 3-(1-piperidinylmethyl)phenol (8.55 g) was heated at 130° C. under nitrogen for 10 minutes. The resulting mixture was dissolved in chloroform (100 ml), washed with 1N sodium hydroxide (2×25 ml), dried (MgSO4) and evaporated to give the title compound as a gum (17.65 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04571394 |
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| Source dataset | uspto-grants-1986_02 |
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| ORD ID | ord-e22734eb9ba445b0aeb8170260e7fe72 |
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| Source note | uspto-grants-1986_02 |
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