Triethylamine → HCID 131714524, compound

Participants

Reaction Steps

A solution of 0.77 g (2.0 mmol) of 7-(2,5-diazabicyclo[2.2.2]oct-2-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, 0.70 ml (8.0 mmol) of 2-bromoethanol, 1.30 ml (8.0 mmol) of triethylamine, and 20 ml of DMF was heated at 100° C. for 18 hours. The reaction solution was evaporated to dryness and the residue was triturated ethanol. The solid was collected by filtration to give 0.61 g of the title product, mp 290° C. dec (a).

Provenance & Evidence