3-(4-chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazole → 1-[4-(1,1,2,2-Tetrafluoroethoxy)phenylcarbamoyl]-3-(4-chlorophenyl)-4-phenyl-2-pyrazoline

Participants

Reaction Steps

1.7 g of 4-(1,1,2,2-tetrafluoroethoxy)phenylisocyanate were added, while stirring, to a suspension of 1.8 g of 3-(4-chlorophenyl)-4-phenyl-2-pyrazoline in 40 ml of dry diethyl ether. After stirring at room temperature for approximately 1 hour 40 ml of petroleum ether (40-60) were added to the reaction mixture, after which stirring at room temperature was continued for another 3 hours. The precipitate formed was sucked off and washed with petroleum ether (40-60). The desired product was obtained in a yield of 3.1 g; melting-point 178°-180° C.

Provenance & Evidence