Salicylaldehyde → HCID 136387293, compound

Participants

Reaction Steps

3-Amino-1-(4-bromo-3-trifluoromethylphenyl)-2-pyrazoline (prepared in Example 39 of our European patent specification No. 22-578) (140 mg) and salicylaldehyde (100 mg) were dissolved together in methanol (2 ml) and 1 drop of glacial acetic acid. The mixture was heated to reflux for 1 hour. During this time a deep orange-red colour developed and the mixture crystallised. It was kept at 0° for 3 hours, then the solid was collected, washed with methanol and dried in vacuo to yield 150 mg 1-(4-bromo-3-trifluoromethylphenyl)-3-(2-hydroxybenzylideneamino)-2-pyrazoline, m.p. 170° (decomp).

Provenance & Evidence