Sulfolane → HCID 9846824, compound

Participants

Reaction Conditions

Reaction Steps

The reactions described in Example 1(a) were repeated, except that 1.5 g of ethyl 3-[4-(6-acetoxy-2,7-dimethylchroman-2-ylmethoxy)phenyl]-2-chloropropionate, 300 mg of thiourea and 2 ml of sulfolane were heated at 120° C. for 2 hours. The reaction mixture was then purified by adding diethyl ether to the reaction mixture, and distilling off the solvent to leave a residue. This residue was purified by column chromatography through silica gel eluted first with a 9:1 by volume mixture of benzene and ethyl acetate, to give the title compound.

Provenance & Evidence