Thionyl Chloride → 2-(4-{[5-(Trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoyl chloride

HRID 1589718Notes

Reaction equation

HRID 1589718 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[CH:5][C:6]([O:9][C:10]2[CH:21]=[CH:20][C:13]([O:14][CH:15]([CH3:19])[C:16](O)=[O:17])=[CH:12][CH:11]=2)=[N:7][CH:8]=1.S(Cl)([Cl:26])=O>>[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[CH:5][C:6]([O:9][C:10]2[CH:21]=[CH:20][C:13]([O:14][CH:15]([CH3:19])[C:16]([Cl:26])=[O:17])=[CH:12][CH:11]=2)=[N:7][CH:8]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 91701Fluazifop

Product 1

HCID 130552202-(4-{[5-(Trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoyl chloride

Procedure

13.1 g (0.04 mol) of 2-[4-(5-trifluoromethyl-2-pyridyloxy)phenoxy]propionic acid (prepared according to example 3 a)) are reacted with 31.4 g (0.25 mol, about 20 ml) of thionyl chloride by boiling under reflux while continuously introducing nitrogen and constantly stirring for 3 hours. After distilling off the excess thionyl chloride with exclusion of moisture under reduced pressure, a distillation residue is obtained which can be directly used for further transformation.

Workup

  1. temperatureunder reflux while continuously introducing nitrogen
  2. distillationAfter distilling off the excess thionyl chloride with exclusion of moisture under reduced pressure
  3. customa distillation residue is obtained which

Sources & evidence

ORD record
ord-a0478076ab5448248d6e52e612dc9cde
Source dataset
uspto-grants-1993_04
Patent number
US05199970

Reaction notes

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