反应详情

13.1 g (0.04 mol) of 2-[4-(5-trifluoromethyl-2-pyridyloxy)phenoxy]propionic acid (prepared according to example 3 a)) are reacted with 31.4 g (0.25 mol, about 20 ml) of thionyl chloride by boiling under reflux while continuously introducing nitrogen and constantly stirring for 3 hours. After distilling off the excess thionyl chloride with exclusion of moisture under reduced pressure, a distillation residue is obtained which can be directly used for further transformation.

1. temperatureunder reflux while continuously introducing nitrogen
2. distillationAfter distilling off the excess thionyl chloride with exclusion of moisture under reduced pressure
3. customa distillation residue is obtained which