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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1589733Generated: November 4, 2026

Hydrochloric Acid → HCID 178479543, compound

https://huagongshe.com/reaction/1589733

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantBenzonitrile, 4-bromo-HCID 12162—
ReactantThionyl ChlorideHCID 24386—
SolventEthanolHCID 702—
ProductHCID 178479543HCID 178479543—

Reaction Steps

Compound [H], 4-bromobenzoic acid is chlorinated with thionyl chloride to yield compound [I], 4-bromobenzoic acid chloride. Compound [I] is reacted with aqueous ammonia to yield compound [J] 4-bromobenzoic acid amide. Compound [J] is dehydrated with thionyl chloride to yield compound [K], a 4-bromobenzonitrile. Compound [K] is reacted with gaseous hydrogen chloride in anhydrous ethanol to yield compound [L], 4-bromobenzimidate hydrogen chloride. In ethanol, compound [L] is reacted with gaseous ammonia to yield compound [M], 4-bromobenzamidine hydrogen chloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05200110
Source datasetuspto-grants-1993_04
ORD IDord-f5c30cdf17ff4cfcb922d02fbd340bb0
Source noteuspto-grants-1993_04