Ammonia → 4-Fluorobenzamidine Hydrochloride

HRID 1589756Notes

Reaction equation

HRID 1589756 reaction equation
[NH3:1].[ClH:2].[F:3][C:4]1[CH:12]=[CH:11][C:7]([C:8](=[NH:10])O)=[CH:6][CH:5]=1>C(O)C>[ClH:2].[F:3][C:4]1[CH:12]=[CH:11][C:7]([C:8]([NH2:1])=[NH:10])=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 1784795464-Fluorobenzimidate hydrogen chloride

Product 1

HCID 124561604-Fluorobenzamidine Hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

310 cm3 of ethanol saturated with ammonia was added to 83 g (0.41 mol) of 4-fluorobenzimidate hydrogen chloride and stirred at room temperature for one day and night. Approximately half of the ethanol was distilled off and the residue was recrystallized to yield 70 g (0.40 mol) of 4-fluorobenzamidine hydrogen chloride.

Workup

  1. distillationApproximately half of the ethanol was distilled off
  2. customthe residue was recrystallized

Sources & evidence

ORD record
ord-ae5e27fedda8416c8fa35477a79cebdf
Source dataset
uspto-grants-1993_04
Patent number
US05200110

Reaction notes

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