Isobutyl 4-oxobutanoate → 2,5-Dioxo-1-ethylhexahydro-1H-pyrrolo[1,2-a]imidazole
반응식
Cl.[CH2:2]([NH:4][C:5](=[O:8])[CH2:6][NH2:7])[CH3:3].O=[CH:10][CH2:11][CH2:12][C:13]([O:15]CC(C)C)=O>>[O:8]=[C:5]1[CH2:6][N:7]2[C:13](=[O:15])[CH2:12][CH2:11][CH:10]2[N:4]1[CH2:2][CH3:3]참가 물질
3
실험 절차
Glycine ethylamide hydrochloride (2.1 g, 15.1 mmol) and isobutyl 4-oxobutanoate (2 g, 12.6 mmol) were reacted together according the procedure of Example 2 to give the title compound, 0.5 g (23.5%) as a viscous oil. Rf=0.51 (silica gel plates, eluent dichloromethane-methanol 9:1). NMR (CDCl3): deltaH =5.27 (t, J=6 Hz, 1H, N--CH--N); 4.20 and 3.45 (ABq, J=17 Hz, 2H, N--CH2 --CO); 3.25 (q, J=7 Hz, 2H, NCH2CH3); 2.70-1.75 (c.a., 4H, COCH2CH2CH); 1.12 (t, J=7 Hz, 3H, CH3). MS (E.I., 70 eV, 1.5 mA) m/z=168 (M+), 112 (M-C3H4O)+, 97 (M-C4H7O)+.
출처 및 근거
- ORD 기록
- ord-1574a23a3f374a2e896a178c5cb7f179
- 출처 데이터셋
- uspto-grants-1993_04
- 특허 번호
- US05200406
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