Dichloromethane → HCID 19770956, compound

Participants

Reaction Steps

Next, 2.41 g (22.7 mmol) of Na2CO3 were added to a solution of 5.0 g (18.9 mmol) of 1-amino-2-propylpyridinium iodide in 20 ml of DMF, followed by stirring at room temperature for 1 hour. Ethyl propiolate (3.71 g; 37.9 mmol) was added further, followed by stirring at room temperature for 20 hours. After the reaction, the reaction mixture was treated in a similar manner to the preparation of the 7-ethyl derivative, whereby 1.45 g (6.25 mmol) of the title compound were obtained as crystals from CH2Cl2 :hexane=1:1 eluate fractions (yield: 33% - 9% in two steps).

Provenance & Evidence